What Are D3s?


What is D3"D3" is just a simple way of saying "DDD" which in our case stands for "Developmental Dental Defect". As the long-winded name suggests, D3s originate from developmental problems – that is, things going awry when the tooth was being formed inside your child's jaw. So D3s can be viewed as a sort of congenital disorder or birth defect, as explained to 6-year-old Sam in our child-friendly storybook.

Several different types of D3 can occur depending on what actually went wrong (e.g. whereabouts in the jaw, when during development, and how badly the problem struck). And so it can be said of D3s that "some
are common and others rare, some affect most teeth, others here
'n' there" (with a hat tip to Ted Geisel). What is D3

Nearly all D3s affect the outward appearance of the tooth enamel – sometimes just a small patch is affected (or "wonky" as your child might say) and other times it’s wonky all over. Such discolourations may not necessarily be of concern if the enamel surface remains sufficiently hard. However, when the patches of abnormal enamel are soft and porous ("chalky"), there is increased risk of toothache and tooth decay (i.e. dental caries) – so dental treatments may be recommended to nip these problems in the bud (read more).

There are four main types of D3 you may hear about, as summarised and cross-compared below.

 

 

1. "CHALKY MOLARS" / "MOLAR HYPOMIN"

Chalky molars are of particular concern to The D3 Group because they are the commonest type of chalky teeth and cause a lot of suffering and costs around the world. Technically, chalky molars are called "Molar Hypomineralisation", or "Molar Hypomin" for short. You can learn many things about Molar Hypomin throughout this website but a good place to start is here.

 

 

2. "FLUOROSIS"

Fluorosis

Fluorosis (or more properly "Dental Fluorosis") refers to the speckled white patches you often see on people's front teeth. Fortunately, most cases of fluorosis in our part of the world are mild and not of dental concern, particularly when the protective "anti-decay" benefits of fluoride are considered. However, there is potential for worse types of fluorosis that exhibit pitted, discoloured enamel – these arise from excessive ingestion of fluoride when the teeth are developing. So that's why there are such strong guidelines about watching how much toothpaste your infants use. Learn more about dental fluorosis here.

 

3. "SURFACE PITS AND GROOVES"

Surface-pits

Surface pits or grooves (technically referred to as "Enamel Hypoplasia") are isolated depressions in the enamel surface. Although quite common they generally don't cause dental concern. But sometimes these pits can trap food and plaque bringing increased risk for decay. The origins of pits and grooves can be traced back to early development of the tooth, when the cells that make enamel get it wrong – instead of producing a nice thick layer of smooth enamel, they can leave gaps here and there which later get solidified as pits when the enamel hardens.  It’s worth knowing that lots of people still get the term "hypoplasia" confused with "hypomineralisation" (as in "Molar Hypomin"), but they are quite different problems as you can find out here.

 

4. "AI"

Al

AI is short for "Amelogenesis Imperfecta" (meaning imperfect enamel formation) and is the worst type of D3 because all teeth are affected usually – but fortunately for most of us, AI is quite rare. This is the only enamel defect that’s regarded as a genetic disorder so there will be a family history in most cases. And perhaps with AI it’s reasonable for kids to be kids and talk about  "mutant teeth", in contrast to the other types of D3 including Molar Hypomin. There are many different types of AI, depending on which gene is affected. Learn more here and here.

 

COMPARING THE MAJOR D3s

Molar Hypomin comes out the overall winner as troublemaker when comparing the four major types of enamel defect. As shown in the figure and table below, whereas AI can be quite devasting for the families concerned, this genetic disorder is relatively rare and so poses a small burden for society. In contrast, Molar Hypomin is the commonest D3, the most costly to society, and often expensive for families (in terms of suffering, time and money). Molar Hypomin damages the 6-year molars of about 1-in-6 children worldwide, and about a quarter of these cases are severe enough to put the child at risk of major decay, extraction and orthodontic need.

To make these comparisons, we have taken a typical version of each disorder as seen in the "new" adult teeth of healthy schoolchildren. Representative numbers are given for well-developed countries, including Australia and NZ, realising that significant differences exist in some other parts of the world. The family and social costs (right axis of graph) are arbitrary estimates only, taking into account prevalence, health risks and economic cost. High-impact features are shaded pink in the table.

The D3G Logo MOLAR HYPOMIN FLUOROSIS PITS & GROOVES
(Enamel Hypoplasia)
AI
(Amelogenesis Imperfecta)
Children affected
(prevalence)
1-in-6 1-in-10
(see footnote 1)
1-in-20
(see footnote 2)
1-in-10,000
Which teeth affected 6-year molars
(+ front teeth sometimes)
Front teeth mostly Any tooth All teeth
How many teeth affected 1 to 4 molars
(2 on average)
All front teeth often Several teeth often Front and back teeth
Adds risk for Toothache, decay Cosmetic issues mostly Decay, cosmetic issues Toothache, decay, cosmetic issues
Dental consequences Fillings, extractions, orthodontic need Cosmetic dentistry Cosmetic dentistry, fillings Fillings, extractions, tooth replacement
Cost to family Medium
(see footnote 3)
Low Low High
Costs to society High Low Low Low
Cause Infantile illness
(see footnote 3)
Fluoride excess Infantile illness Genetic mutation
Preventable? Potentially Yes Largely No

Notes

  1. Dental fluorosis (mild/moderate/severe) prevalence is much higher in some regions due to naturally
    high levels of fluoride in drinking water and/or dietary habits.
  2. As enamel hypoplasia prevalence (1% in the cited NZ study) is much higher in some regions lacking
    in paediatric healthcare an arbitrary value of 5% is used.
  3. Often being abnormally crumbly, Molar Hypomin teeth can be tricky to repair and so fillings frequently
    don't last as long as usual.

OTHER TYPES OF D3

There are many other things that can go wrong during tooth development besides the four major enamel defects. Some such dental malformations primarily involve enamel (e.g. ectopic enamel, enamel pearl) or dentine (e.g. dentinogenesis imperfecta, dentine dysplasia), or both (tetracycline staining), whereas others affect the number of teeth (e.g. anodontia, hypodontia, hyperdontia) or their size and shape (e.g. microdontia, macrodontia, taurodontism, tooth fusion, gemination, dens evanginatus, supernumerary rootsectodermal dysplasia, tricho-dento-osseous syndrome, solitary median maxillary central incisor). All of these conditions are important (particularly to those suffering them!) and we hope that, in time, The D3 Group will be able to give them due attention.