BREAKTHROUGH SCIENCE

Pathogenesis Of Molar Hypomineralisation

Vidal Gels image

A 100-year mystery about "chalky enamel spots" (demarcated opacities) – a principal risk factor for childhood tooth decay – is well on the way to being solved thanks to ground-breaking molecular investigations by D3G's lead researchers (see origins here & here). Until now, it has been difficult to understand why developmental disruption is limited to isolated spots or patches of enamel. Researchers have long believed that corresponding patches of enamel-forming cells must be selectively damaged in some way – but how such localised cellular injuries might link to "whole body" (systemic) disturbances such as infantile illness
remains an enigma. The new findings switch attention to the developing enamel itself (i.e. extracellular matrix, rather than
injured enamel cells) and show that chalky spots arise from
localised exposure to a prominent protein from blood called
serum albumin. This extracellular pathomechanism, termed
'mineralisation poisoning', opens an exciting new direction
for investigations into the medical prevention of Molar Hypomin
and allied tooth decay.

(Part 1)

Frontiers Article - Pathogenesis of Molar Hypomineralisation: Hypomineralised 6-Year Molars Contain Traces of Fetal Serum Albumin pic

Pathogenesis of Molar Hypomineralisation: Hypomineralised 6-year molars contain traces of fetal serum albumin
Williams R, Perez VA, Mangum JE, Hubbard MJ (2020) Frontiers Physiol, 11, 619

Free download here.





(Part 2)

Frontiers Article - Pathogenesis of Molar Hypomineralisation: Aged albumin demarcates chalky regions of hypomineralised enamel pic

Pathogenesis of Molar Hypomineralisation: Aged albumin demarcates chalky regions of hypomineralised enamel
Perez VA, Mangum JE, Hubbard MJ (2020) Frontiers Physiol, 11, 579015

Free download here.





PUBLICATIONS ABOUT D3G

Academic articles

Several articles outlining D3G, the Chalky Teeth Campaign, the "Molar Hypomineralisation problem" and the Chalky Teeth Centenary appeared in highly regarded academic journals recently. These were bolstered by a "chalky teeth feature" (3 articles) in a national dental publication.

Importantly, these cross-referenced articles have broken new ground by introducing D3G's "translational terminology" ("D3s", "chalky teeth", "chalky molars" etc) to the academic literature following successful road-testing on the public and practitioners. This advance provides a rare example of "reverse translation" – most talk today is about the other direction (converting academic advances to public good), but clearly both directions matter. For more information see D3G News Sept 2018 and May 2018.


Frontiers pic

100 years of chalky teeth research: From pioneering histopathology to social good
Hubbard MJ, Perez VA, Ganss B (2021) Frontiers Dent Med, 1, 632534

Free download here.





Paediatric Dental article pic

Molar hypomineralization: What is the U.S. experience (revisited)?
Hubbard MJ (2020) Pediatr Dent, 15, 414-5

Personal download here.






JADA article pic

Chalky teeth 100 years on: What comes next?
Hubbard MJ (2020) J Am Dent Assoc, 151, 803-5

Personal download here






NZDA News image

The Molar Hypomineralisation problem: translational science, paediatric and orthodontic perspectives (3 articles)
Hubbard MJ, Natarajan A, Antoun A, Firth F (2019) NZDA News, 195, 35-60

Free download here (thanks to NZDA).






JADA image

Molar Hypomineralization: What is the US experience?
Hubbard MJ (2018) J Am Dent Assoc, 149, 329-30

Free download here.






Frontiers image

Molar Hypomineralisation: A call to arms for enamel researchers
Hubbard MJ, Mangum JE, Perez VA, Nervo GJ, Hall RK (2017) Frontiers Physiol, 8, 546

Free download here.



EDUCATIONAL VIDEOS AND PODCAST

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Continuing education webinar on Molar Hypomineralisation

(Colgate Oral Health Network, USA)

November 2018

Colgate America kindly hosted a free webinar in support of D3G's Chalky Teeth Campaign. This uniquely "D3-flavoured" lecture by Erin Mahoney and Mike Hubbard attracted a record live attendance and is now used by dental schools around the world. For more information, including Colgate's poll about practitioners' awareness of Molar Hypomin, see D3G News November 2018.

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Watch here, requires free registration (70 minutes, 1 hour CE credit).




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Continuing education podcast on Molar Hypomineralisation

(ADA-NSW, Australia)

March 2019

Kindly hosted by the New South Wales branch of the Australian Dental Association, Mike Hubbard talks about clinical aspects of Molar Hypomineralisation through a translational lens.

Listen here (23 minutes).


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Continuing education lecture on Molar Hypomineralisation and The Chalky Teeth Campaign

(DHSV, Australia)

June 2016

At the Public Oral Health Innovations Conference hosted in Melbourne by Dental Health Services Victoria, Mike Hubbard talks about Molar Hypomin and The Chalky Teeth Campaign.

Watch here (14 minutes).


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How it all started – a unique conversation with D3 pioneer, Grace Suckling

(The D3 Group)

August 2013

More than anyone, Grace Suckling defined our field. How did she get interested in D3 research, what led to the clinical classifications (DDE Index) still used worldwide today, how were the pathological differences between hypoplasia, hypomineralisation and fluorosis established? These and many more questions are answered in a wonderful conversation with modern-day researcher and paedodontist, Erin Mahoney.

Watch here (36 minutes). An edited version (4 minutes) and much
more information about Grace's work is available here.

D3G IN THE NEWS

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ABC Radio Australia interview

February 2019

Mike Hubbard talks about "chalky teeth", Molar Hypomin and the Chalky Teeth Campaign. Listen here (12 minutes).


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Australian Bite Magazine feature on dental innovators

December 2018

The D3 Group and Mike Hubbard are featured in an article about "5 visionary Australians transforming dentistry". Read here.



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Radio New Zealand interview

October 2018

New Zealand D3G representative Dorothy Boyd and Mike Hubbard talk about "chalky teeth", Molar Hypomin and the Chalky Teeth Campaign. Listen here (10 minutes).




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Article in Bite magazine

September 2014

D3G founder, Mike Hubbard, relays his vision and experiences in establishing D3G as a world-first translational research and education network centred on understanding and care of people with D3s. Read here.



D3G's "Chalky Teeth" campaign launch


August 2013


D3G's Chalky Teeth Campaign was launched alongside our new online education resource and medico-dental initiative (see D3G News, August 24 2013 and Past Events). Pleasingly, our adoption of "chalky teeth" as a public-friendly term for Molar Hypomin (and other D3s) seemed to gain immediate acceptance from the broader media and public. Within a week, the "1-in-6 kids have chalky teeth" story had been picked up nationally (TV, radio, papers) and internationally, leading to >40 reports worldwide. This exposure led to a major surge in website traffic and correspondence received from across the sector.


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ABC News Pic

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